When to Spay/Neuter Your Guinea Pig or Rabbit
Female Guinea Pigs and Rabbits
o As young as 2 to 3 months (small rabbit breeds and guinea pigs) and 6 months (larger rabbit breeds)
Male Guinea Pigs and Rabbitso When appropriate 12 to 16 weeks of age.
NOTE: If you plan on breeding your guinea pigs, the female should be under 6 months of age as their pubic bones fuse by that age which could lead to dystocia (difficulty birthing) if bred after 6 months of age.